Sodium tetradecyl sulfate
Sotradecol, Tetradecyl (sodium tetradecyl sulfate) is a small molecule pharmaceutical. Sodium tetradecyl sulfate was first approved as Sotradecol on 1982-01-01. It is used to treat esophageal and gastric varices and varicose veins in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| digestive system diseases | D004066 |
| cardiovascular diseases | D002318 |
Trade Name
FDA
EMA
Sotradecol, Tetradecyl (discontinued: Sotradecol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sodium tetradecyl sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SOTRADECOL | A.H. Robins Company | N-005970 DISCN | 1982-01-01 | 2 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| (sotradecol) sodium tetradecyl sulfate | ANDA | 2021-06-25 |
| sodium tetradecyl sulfate | ANDA | 2024-06-26 |
| sotradecol | ANDA | 2021-08-17 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| esophageal and gastric varices | EFO_0009545 | D004932 | I85 |
| varicose veins | — | D014648 | I83.90 |
Agency Specific
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Clinical
Clinical Trials
24 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Varicose veins | D014648 | — | I83.90 | — | — | — | 2 | 5 | 7 |
| Venous insufficiency | D014689 | — | — | — | 1 | — | 1 | 3 | 5 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | — | — | 1 | — | 1 |
| Vascular malformations | D054079 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibrosis | D005355 | — | — | — | — | 1 | — | 1 | 2 |
| Esophageal and gastric varices | D004932 | EFO_0009545 | I85 | — | — | 1 | — | 1 | 2 |
| Hepatic insufficiency | D048550 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hereditary hemorrhagic telangiectasia | D013683 | — | I78.0 | 1 | 1 | — | — | — | 1 |
| Epistaxis | D004844 | EFO_0003895 | R04.0 | 1 | 1 | — | — | — | 1 |
| Cysts | D003560 | — | — | — | 1 | — | — | — | 1 |
| Epidermal cyst | D004814 | — | K09.8 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | 1 | — | — | — | 4 | 5 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | — | — | — | — | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | — | 1 |
| Chronic fatigue syndrome | D015673 | EFO_0004540 | G93.31 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myofascial pain syndromes | D009209 | EFO_1001054 | — | — | — | — | — | 4 | 4 |
| Varicose ulcer | D014647 | — | — | — | — | — | — | 2 | 2 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | — | — | — | 1 | 1 |
| Thromboembolism | D013923 | — | — | — | — | — | — | 1 | 1 |
| Telangiectasis | D013684 | — | — | — | — | — | — | 1 | 1 |
| Sclerotherapy | D015911 | — | — | — | — | — | — | 1 | 1 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 1 | 1 |
| Arteritis | D001167 | EFO_0009011 | I77.6 | — | — | — | — | 1 | 1 |
| Recurrence | D012008 | — | — | — | — | — | — | 1 | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Sodium tetradecyl sulfate |
| INN | sodium tetradecyl sulfate |
| Description | Sodium tetradecyl sulfate (STS) is a common anionic surfactant. The compound consists of the sodium salt of the micelle-forming sulfate ester of tetradecanol. It is a white, water-soluble solid of low toxicity with many practical uses.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCC(CC)CCC(CC(C)C)OS(=O)(=O)[O-].[Na+] |
Identifiers
| PDB | — |
| CAS-ID | 139-88-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200354 |
| ChEBI ID | 75273 |
| PubChem CID | 14492 |
| DrugBank | — |
| UNII ID | Q1SUG5KBD6 (ChemIDplus, GSRS) |
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Safety
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125 adverse events reported
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